Application of three-dimensional culture conditions to human embryonic stem cell-derived definitive endoderm cells enhances hepatocyte differentiation and functionality

• Main Authors: Ramasamy, T.S., Yu, J.S.L., Selden, C., Hodgson, H., Cui, W.
• Format: Article
• Language: English
• Published: 2013
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/9241/1/TS_ramasamy_tissue_engineering_2013.pdf; http://eprints.um.edu.my/9241/; http://online.liebertpub.com/doi/abs/10.1089/ten.tea.2012.0190
• Institution: Universiti Malaya

Human embryonic stemcells (hESCs) and induced pluripotent stemcells (iPSCs) provide an unlimited source for the generation of human hepatocytes, owing to their indefinite self-renewal and pluripotent properties. Both hESC-/iPSC-derived hepatocytes hold great promise in treating liver diseases as pot...