New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found th...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
John Wiley & Sons, Inc.
2008
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| Subjects: | |
| Online Access: | http://dspace.unimap.edu.my/xmlui/handle/123456789/1503 |
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| Institution: | Universiti Malaysia Perlis |
| Language: | English |
| Summary: | For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found the additional constraints between the parameters. These relations allow to predict in which situation rate constants are identifiable by steady-state kinetic methods. |
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