New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants

For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found th...

Full description

Saved in:

Bibliographic Details
Main Authors:	Straathof, A. J. J., Heijnen, J. J.
Format:	Article
Language:	English
Published:	John Wiley & Sons, Inc. 2008
Subjects:	Enzyme kinetics. Parameter estimation.
Online Access:	http://dspace.unimap.edu.my/xmlui/handle/123456789/1503
Tags:	Add Tag No Tags, Be the first to tag this record!
Institution:	Universiti Malaysia Perlis
Language:	English

id	my.unimap-1503
record_format	dspace
spelling	my.unimap-15032008-08-07T01:22:45Z New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants Straathof, A. J. J. Heijnen, J. J. Enzyme kinetics. Parameter estimation. For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found the additional constraints between the parameters. These relations allow to predict in which situation rate constants are identifiable by steady-state kinetic methods. 2008-08-07T01:22:45Z 2008-08-07T01:22:45Z 1996 Article Biotechnology and Bioengineering, vol. 52, issue 3, 1996, pages 433-437 00063592 http://hdl.handle.net/123456789/1503 en John Wiley & Sons, Inc.
institution	Universiti Malaysia Perlis
building	UniMAP Library
collection	Institutional Repository
continent	Asia
country	Malaysia
content_provider	Universiti Malaysia Perlis
content_source	UniMAP Library Digital Repository
url_provider	http://dspace.unimap.edu.my/
language	English
topic	Enzyme kinetics. Parameter estimation.
spellingShingle	Enzyme kinetics. Parameter estimation. Straathof, A. J. J. Heijnen, J. J. New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
description	For an enzymatic reaction the rate constants in the assumed mechanism (k1,k_1, etc.)sometimes cannot. When identifiability problems occur, these are obscured by redundancy occurring among the steady-state parameters. This redundancy is only partly revealed by the known Haldane relations. We found the additional constraints between the parameters. These relations allow to predict in which situation rate constants are identifiable by steady-state kinetic methods.
format	Article
author	Straathof, A. J. J. Heijnen, J. J.
author_facet	Straathof, A. J. J. Heijnen, J. J.
author_sort	Straathof, A. J. J.
title	New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_short	New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_full	New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_fullStr	New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_full_unstemmed	New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
title_sort	new constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants
publisher	John Wiley & Sons, Inc.
publishDate	2008
url	http://dspace.unimap.edu.my/xmlui/handle/123456789/1503
_version_	1643787340235145216

New constraints between kinetic parameters explain the (un)identifiability of enzymatic rate constants

Similar Items