Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression

Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression

antidiabetic agent; C peptide; glibenclamide; glucose; glucose transporter 1; glucose transporter 2; glucose transporter 4; glutathione; insulin; interleukin 1beta; interleukin 6; nicotinamide; plant extract; Pseuduvaria macrophylla extract; transforming growth factor beta1; tumor necrosis factor; u...

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Main Authors: Taha H., Arya A., Khan A.K., Shahid N., Noordin M.I.B., Mohan S.
Other Authors: 54279619100
Format: Article
Published: University of South Bohemia 2023
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spelling my.uniten.dspace-236322023-05-29T14:50:38Z Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression Taha H. Arya A. Khan A.K. Shahid N. Noordin M.I.B. Mohan S. 54279619100 55089467500 56883447200 56257862800 6602281241 26424414900 antidiabetic agent; C peptide; glibenclamide; glucose; glucose transporter 1; glucose transporter 2; glucose transporter 4; glutathione; insulin; interleukin 1beta; interleukin 6; nicotinamide; plant extract; Pseuduvaria macrophylla extract; transforming growth factor beta1; tumor necrosis factor; unclassified drug; animal cell; animal experiment; animal model; animal tissue; Annonaceae; antidiabetic activity; Article; body weight; controlled study; glucose blood level; histopathology; immunohistochemistry; inflammation; insulin blood level; insulin level; insulin release; insulin signaling; lipid peroxidation; non insulin dependent diabetes mellitus; nonhuman; oxidative stress; pancreas islet; pancreas islet beta cell; pancreas tissue; peroxidation; protein expression; Pseuduvaria macrophylla; rat; toxicity testing Pseuduvaria macrophylla (Family: Annonaceae) is commonly used as medicinal plant in Malaysia. A recent study with the Pseuduvaria species showed antioxidant and antidiabetic effects. This study aimed to ascertain antidiabetic potential of methanolic extract of Pseuduvaria macrophylla bark (PM) using streptozotocin-nicotinamide induced diabetic rat models. Various phytochemical and biochemical properties of the plant have been evaluated. The results showed that the extract has potentially normalized the elevated blood glucose levels by upregulating the insulin and C-peptide levels and alleviated oxidative stress by improving glutathione (GSH) and reducing lipid peroxidation (LPO) in the diabetic rats. In addition, PM has drastically downregulated the levels of pro-inflammatory cytokines and transforming growth factor beta-1 (TGF-?1). Histopathological examination of the pancreas in PM treated diabetic rats showed significant recovery of the pancreatic structural degeneration and thus reflected the protective role of PM against peroxidation damage by a rise in insulin level as evidenced by the immunohistochemistry study. The improved expressions of GLUT-1, GLUT-2 and GLUT-4 further confirmed the restoration of ?-cell mass by PM. Interestingly, the findings demonstrated the antioxidant, anti-inflammatory and antihyperglycemic potential of PM which may provide future lead for the management of type-2 diabetes. � 2018 Faculty of Health and Social Sciences, University of South Bohemia in Ceske Budejovice Final 2023-05-29T06:50:37Z 2023-05-29T06:50:37Z 2018 Article 10.1016/j.jab.2018.05.004 2-s2.0-85047425129 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047425129&doi=10.1016%2fj.jab.2018.05.004&partnerID=40&md5=7b3874b26af11abedac7009078e71e37 https://irepository.uniten.edu.my/handle/123456789/23632 16 4 263 273 University of South Bohemia Scopus
institution Universiti Tenaga Nasional
building UNITEN Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Tenaga Nasional
content_source UNITEN Institutional Repository
url_provider http://dspace.uniten.edu.my/
description antidiabetic agent; C peptide; glibenclamide; glucose; glucose transporter 1; glucose transporter 2; glucose transporter 4; glutathione; insulin; interleukin 1beta; interleukin 6; nicotinamide; plant extract; Pseuduvaria macrophylla extract; transforming growth factor beta1; tumor necrosis factor; unclassified drug; animal cell; animal experiment; animal model; animal tissue; Annonaceae; antidiabetic activity; Article; body weight; controlled study; glucose blood level; histopathology; immunohistochemistry; inflammation; insulin blood level; insulin level; insulin release; insulin signaling; lipid peroxidation; non insulin dependent diabetes mellitus; nonhuman; oxidative stress; pancreas islet; pancreas islet beta cell; pancreas tissue; peroxidation; protein expression; Pseuduvaria macrophylla; rat; toxicity testing
author2 54279619100
author_facet 54279619100
Taha H.
Arya A.
Khan A.K.
Shahid N.
Noordin M.I.B.
Mohan S.
format Article
author Taha H.
Arya A.
Khan A.K.
Shahid N.
Noordin M.I.B.
Mohan S.
spellingShingle Taha H.
Arya A.
Khan A.K.
Shahid N.
Noordin M.I.B.
Mohan S.
Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
author_sort Taha H.
title Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
title_short Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
title_full Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
title_fullStr Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
title_full_unstemmed Effect of Pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in STZ-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
title_sort effect of pseuduvaria macrophylla in attenuating hyperglycemia mediated oxidative stress and inflammatory response in stz-nicotinamide induced diabetic rats by upregulating insulin secretion and glucose transporter-1, 2 and 4 proteins expression
publisher University of South Bohemia
publishDate 2023
_version_ 1806427748898439168

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