Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH

Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH

Poly (ADP-ribose) polymerases (PARPs) play diverse roles in various cellular processes that involve DNA repair and programmed cell death. Amongst these polymerases is PARP-1 which is the key DNA damage-sensing enzyme that acts as an initiator for the DNA repair mechanism. Dihydroorotate dehydrogenas...

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Bibliographic Details
Main Authors: Abdullah, I., Chee, C.F., Lee, Y.-K., Thunuguntla, S.S.R., Satish Reddy, K., Nellore, K., Antony, T., Verma, J., Mun, K.W., Othman, S., Subramanya, H., Rahman, N.A.
Format: Article
Language:English
Published: 2017
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Institution: Universiti Tenaga Nasional
Language: English

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