Benzimidazole derivatives as potential dual inhibitors for PARP-1 and DHODH

• Main Authors: Abdullah, I., Chee, C.F., Lee, Y.-K., Thunuguntla, S.S.R., Satish Reddy, K., Nellore, K., Antony, T., Verma, J., Mun, K.W., Othman, S., Subramanya, H., Rahman, N.A.
• Format: Article
• Language: English
• Published: 2017
• Institution: Universiti Tenaga Nasional

Poly (ADP-ribose) polymerases (PARPs) play diverse roles in various cellular processes that involve DNA repair and programmed cell death. Amongst these polymerases is PARP-1 which is the key DNA damage-sensing enzyme that acts as an initiator for the DNA repair mechanism. Dihydroorotate dehydrogenas...