Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such...
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| Main Authors: | , , |
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| Format: | Conference or Workshop Item |
| Language: | English |
| Published: |
Asia Pacific Association of Allergy, Asthma, and Clinical Immunology
2024
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| Online Access: | http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf http://psasir.upm.edu.my/id/eprint/115329/ |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement. |
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