Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome

Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such...

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Main Authors: Ismail, Intan Hakimah, Zainal Abidin, Mohd Azri, Mohamed Nashrudin, Khairoon Nisa
Format: Conference or Workshop Item
Language:English
Published: Asia Pacific Association of Allergy, Asthma, and Clinical Immunology 2024
Online Access:http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf
http://psasir.upm.edu.my/id/eprint/115329/
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Institution: Universiti Putra Malaysia
Language: English
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spelling my.upm.eprints.1153292025-03-03T05:11:03Z http://psasir.upm.edu.my/id/eprint/115329/ Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement. Asia Pacific Association of Allergy, Asthma, and Clinical Immunology 2024 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf Ismail, Intan Hakimah and Zainal Abidin, Mohd Azri and Mohamed Nashrudin, Khairoon Nisa (2024) Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome. In: Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) Congress 2024, 13-15 Dec. 2024, Kuala Lumpur, Malaysia. .
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement.
format Conference or Workshop Item
author Ismail, Intan Hakimah
Zainal Abidin, Mohd Azri
Mohamed Nashrudin, Khairoon Nisa
spellingShingle Ismail, Intan Hakimah
Zainal Abidin, Mohd Azri
Mohamed Nashrudin, Khairoon Nisa
Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
author_facet Ismail, Intan Hakimah
Zainal Abidin, Mohd Azri
Mohamed Nashrudin, Khairoon Nisa
author_sort Ismail, Intan Hakimah
title Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
title_short Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
title_full Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
title_fullStr Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
title_full_unstemmed Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
title_sort aspergilloma in a young patient with autosomal-dominant hyper-ige syndrome
publisher Asia Pacific Association of Allergy, Asthma, and Clinical Immunology
publishDate 2024
url http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf
http://psasir.upm.edu.my/id/eprint/115329/
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