Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome
Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such...
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Asia Pacific Association of Allergy, Asthma, and Clinical Immunology
2024
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my.upm.eprints.1153292025-03-03T05:11:03Z http://psasir.upm.edu.my/id/eprint/115329/ Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement. Asia Pacific Association of Allergy, Asthma, and Clinical Immunology 2024 Conference or Workshop Item PeerReviewed text en http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf Ismail, Intan Hakimah and Zainal Abidin, Mohd Azri and Mohamed Nashrudin, Khairoon Nisa (2024) Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome. In: Asia Pacific Association of Allergy, Asthma, and Clinical Immunology (APAAACI) Congress 2024, 13-15 Dec. 2024, Kuala Lumpur, Malaysia. . |
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Signal transducer and activator of transcription 3 (STAT3) deficiency is the primary cause of autosomal dominant hyper IgE syndrome (AD-HIES), also known as Job syndrome. Approximately 90% of affected individuals experience bacterial pneumonia, with about 67% developing pulmonary complications such as bronchiectasis or pneumatoceles. Moreover, STAT3 deficiency significantly predisposes patients to fungal infections, particularly aspergillosis. Aspergilloma, often referred to as a mycetoma or fungal ball, is the most frequent pulmonary manifestation of Aspergillus species, typically forming within preexisting lung cavities. Diagnosis relies on a combination of radiographic findings and serological or microbiological evidence of Aspergillus involvement. |
format |
Conference or Workshop Item |
author |
Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa |
spellingShingle |
Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
author_facet |
Ismail, Intan Hakimah Zainal Abidin, Mohd Azri Mohamed Nashrudin, Khairoon Nisa |
author_sort |
Ismail, Intan Hakimah |
title |
Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
title_short |
Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
title_full |
Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
title_fullStr |
Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
title_full_unstemmed |
Aspergilloma in a young patient with autosomal-dominant hyper-IgE syndrome |
title_sort |
aspergilloma in a young patient with autosomal-dominant hyper-ige syndrome |
publisher |
Asia Pacific Association of Allergy, Asthma, and Clinical Immunology |
publishDate |
2024 |
url |
http://psasir.upm.edu.my/id/eprint/115329/1/115329.pdf http://psasir.upm.edu.my/id/eprint/115329/ |
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