Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 a...

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Bibliographic Details
Main Authors: Sulaiman, Mohd Roslan, Perimal, Enoch Kumar, Akhtar, Muhammad Nadeem, Tengku Mohamad, Tengku Azam Shah, Khalid, Mohamed Hanief, Tasrip, Nor Asmara, Mokhtar, Fuzi, Zakaria, Zainul Amiruddin, Lajis, Nordin, Israf Ali, Daud Ahmad
Format: Article
Published: Elsevier 2010
Online Access:http://psasir.upm.edu.my/id/eprint/13154/
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Institution: Universiti Putra Malaysia
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Summary:The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.

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