Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.

• Main Authors: Sulaiman, Mohd Roslan, Perimal, Enoch Kumar, Akhtar, Muhammad Nadeem, Tengku Mohamad, Tengku Azam Shah, Khalid, Mohamed Hanief, Tasrip, Nor Asmara, Mokhtar, Fuzi, Zakaria, Zainul Amiruddin, Lajis, Nordin, Israf Ali, Daud Ahmad
• Format: Article
• Published: Elsevier 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/13154/
• Institution: Universiti Putra Malaysia

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.