Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities

• Main Authors: Ka-Heng, Lee, Ab. Aziz, Farida Haryani, Ahmad, Syahida, Abas, Faridah, Shaari, Khozirah, Israf Ali, Daud Ahmad, Lajis, Nordin
• Format: Article
• Language: English; English
• Published: Elsevier 2009
• Online Access: http://psasir.upm.edu.my/id/eprint/16920/1/Synthesis%20and%20biological%20evaluation%20of%20curcumin.pdf; http://psasir.upm.edu.my/id/eprint/16920/
• Institution: Universiti Putra Malaysia

A series of 46 curcumin related diarylpentanoidanalogues were synthesized and evaluated for their anti-inflammatory, antioxidant and anti-tyrosinaseactivities. Among these compounds 2, 13 and 33 exhibited potent NO inhibitory effect on IFN-γ/LPS-activated RAW 264.7 cells as compared to l-NAME and cu...