Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach

Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cellsthrough the intrinsic pathway with involvement of NF-kB signalling andG0/G1 cell cycle arrest : a bioassay-guided approach

Ethnopharmacological relevance: Clausena excavata Burm. f. has been used in folk medicines in eastern Thailand for the treatment of cancer. Materials and methods: To investigate the apoptosis mechanism, we isolated dentatin (DTN) from this plant using a bioassay-guided approach. DTN-induced cytot...

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Main Authors: Arbab, Ismail Adam, Abdul, Ahmad Bustamam, Sukari, Mohd Aspollah, Abdullah, Rasedee, Syam, Suvitha, Kamalidehghan, Behnam, Ibrahim, Mohamed Yousif, Elhassan Taha, Manal Mohamed, Abdelwahab, Siddig Ibrahim, Mohd Ali, Hapipah, Mohan, Syam
Format: Article
Language:English
Published: Elsevier 2013
Online Access:http://psasir.upm.edu.my/id/eprint/30034/1/Dentatin%20isolated%20from%20Clausena%20excavata%20induces%20apoptosis%20in%20MCF.pdf
http://psasir.upm.edu.my/id/eprint/30034/
http://dx.doi.org/10.1016/j.jep.2012.11.020
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Institution: Universiti Putra Malaysia
Language: English

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http://psasir.upm.edu.my/id/eprint/30034/1/Dentatin%20isolated%20from%20Clausena%20excavata%20induces%20apoptosis%20in%20MCF.pdf
http://psasir.upm.edu.my/id/eprint/30034/
http://dx.doi.org/10.1016/j.jep.2012.11.020

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