NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide

• Main Authors: Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sumon, Shariful Hasan, Mohamad Sidik, Shiran, Phillips, Roger, Lajis, Nordin, Stanslas, Johnson
• Format: Article
• Published: Elsevier 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/34632/; http://www.sciencedirect.com/science/article/pii/S1382668914001707
• Institution: Universiti Putra Malaysia

Andrographolide (AGP) is the main bioactive constituent isolated from the traditional medicinal, Andrographis paniculata which contributes towards its various biological activities, including anticancer property. In this study, a series of new AGP derivatives were semi-synthesised and screened again...