Angiotensin II stimulates expression of transcription factors c-Jun and c-Fos in cyclosporine induced human gingival fibroblasts
The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibro- blast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analy...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Centro Regional de Investigaciones Cientificas y Tecnologicas
2014
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| Online Access: | http://psasir.upm.edu.my/id/eprint/36461/1/Angiotensin%20II%20stimulates%20expression%20of%20transcription%20factors%20c.pdf http://psasir.upm.edu.my/id/eprint/36461/ http://www.cricyt.edu.ar/biocell/vol/37_3.html |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | The present study demonstrates that the expression of c-Jun and c-Fos are elevated in gingival fibro- blast cells treated with angiotensin II and cyclosporine. The healthy human gingival tissues were collected and gingival fibroblasts were isolated and cultured. We used RT-PCR and Western blot analysis to identify the expression of c-Jun and c-Fos in cyclosporine and angiotensin II treated human gingival fibroblast cells. We found that angiotensin II in combination with cyclosporine induces c-Jun and c-Fos expressions significantly; however, the angiotensin II antagonist losartan inhibits the expression of c-Jun and c-Fos (p < 0.01). The data suggest that angiotensin II in combination with cyclosporine modulates the expression of c-Jun and c-Fos in human gingival fibroblast cells. |
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