Antioxidant and anti-ulcer effects of ethyl acetate fraction of Merremia tridentata (L.) Hallier f. root

• Main Authors: Sowndhararajan, Kandhasamy, Chin, Nyuk Ling
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/36491/1/Antioxidant%20and%20Anti-Ulcer%20Effects%20of%20Ethyl%20Acetate%20Fraction%20of.pdf; http://psasir.upm.edu.my/id/eprint/36491/
• Institution: Universiti Putra Malaysia

The present study was aimed to determine the antioxidant and anti-ulcer effects of Merremia tridentata root (Arrow-leaf Morning Glory). Antioxidant potential of crude acetone extract and its fractions was evaluated by using various in vitro assays. In the anti-ulcer study, pre-treatment with ethyl acetate fraction (MEF) (50, 100 and 200 mg/kg b.wt.) significantly protected the ethanol-induced gastric ulcer in rats. Simultaneously, the antioxidant enzyme levels of superoxide dismutase, catalase and glutathione in the stomach tissues were significantly increased while pre-treated with MEF. From the results, MEF has the therapeutical potential to prevent gastric ulceration induced by ethanol.