Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet
Purpose – The purpose of this paper is to report on the anti-cholesterol activities of Ganoderma lucidum on Sprague–Dawley white rats. Design/methodology/approach – Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Emerald Group Publishing
2008
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/7323/1/Efficacy%20of%20Ganoderma%20lucidum%20on%20plasma%20lipids%20and%20lipoproteins%20in%20rats%20fed%20with%20high%20cholesterol%20diet.pdf http://psasir.upm.edu.my/id/eprint/7323/ http://www.emeraldinsight.com/doi/abs/10.1108/00346650810871911 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | Purpose – The purpose of this paper is to report on the anti-cholesterol activities of Ganoderma lucidum on Sprague–Dawley white rats.
Design/methodology/approach – Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for a period of six months. At regular intervals, blood samples were taken and analysed for the total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C) levels.
Findings – Administration of hyperlipidemia diet in rats fed with 1 per cent cholesterol diet caused an increase in the TC, TG, as well as LDL-C level as compared to the control. A decrease of 23.6 per cent in the HDL-C level was also noted. However, supplementation of the feed with G. lucidum (0.1 per cent) in rats decreased the TC, TG and LDL-C level significantly (P < 0.05) while further increased the plasma concentration of HDL-C. In the case of rats fed with diet containing a mixture of 1 per cent cholesterol and 0.1 per cent of Ganoderma, the lipid profile showed much higher readings (p < 0.05) compared to the chol group.
Practical implications – The possible efficacy of G. lucidum in reducing the deposition of cholesterol in the wall of the blood vessels was indicated.
Originality/value – This article provides useful information to health care providers and consumers. |
|---|