Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet

• Main Authors: Tong, Chow Chin, Choong, Yew Keong, Mohamed, Suhaila, Mohamed Mustapha, Noordin, Umar, Nor Aini
• Format: Article
• Language: English
• Published: Emerald Group Publishing 2008
• Online Access: http://psasir.upm.edu.my/id/eprint/7323/1/Efficacy%20of%20Ganoderma%20lucidum%20on%20plasma%20lipids%20and%20lipoproteins%20in%20rats%20fed%20with%20high%20cholesterol%20diet.pdf; http://psasir.upm.edu.my/id/eprint/7323/; http://www.emeraldinsight.com/doi/abs/10.1108/00346650810871911
• Institution: Universiti Putra Malaysia

Purpose – The purpose of this paper is to report on the anti-cholesterol activities of Ganoderma lucidum on Sprague–Dawley white rats. Design/methodology/approach – Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for a period of six months. At regular intervals, blood samples were taken and analysed for the total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C) levels. Findings – Administration of hyperlipidemia diet in rats fed with 1 per cent cholesterol diet caused an increase in the TC, TG, as well as LDL-C level as compared to the control. A decrease of 23.6 per cent in the HDL-C level was also noted. However, supplementation of the feed with G. lucidum (0.1 per cent) in rats decreased the TC, TG and LDL-C level significantly (P < 0.05) while further increased the plasma concentration of HDL-C. In the case of rats fed with diet containing a mixture of 1 per cent cholesterol and 0.1 per cent of Ganoderma, the lipid profile showed much higher readings (p < 0.05) compared to the chol group. Practical implications – The possible efficacy of G. lucidum in reducing the deposition of cholesterol in the wall of the blood vessels was indicated. Originality/value – This article provides useful information to health care providers and consumers.