Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with dif...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Institute of Electrical and Electronics Engineers
2019
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| Online Access: | http://psasir.upm.edu.my/id/eprint/81089/1/EPROTEIN.pdf http://psasir.upm.edu.my/id/eprint/81089/ https://ieeexplore.ieee.org/document/8384018 |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10–9 M–1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue
diagnostics. |
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