Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with dif...
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Institute of Electrical and Electronics Engineers
2019
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my.upm.eprints.810892020-10-12T07:47:05Z http://psasir.upm.edu.my/id/eprint/81089/ Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor Abu Bakar, Muhammad Hafiz Mahdi, Mohd Adzir Yaacob, Mohd Hanif Amir Hamzah, Amir Syahir Lim, Hong Ngee Mustapha Kamil, Yasmin We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10–9 M–1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue diagnostics. Institute of Electrical and Electronics Engineers 2019 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/81089/1/EPROTEIN.pdf Abu Bakar, Muhammad Hafiz and Mahdi, Mohd Adzir and Yaacob, Mohd Hanif and Amir Hamzah, Amir Syahir and Lim, Hong Ngee and Mustapha Kamil, Yasmin (2019) Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor. IEEE Journal of Selected Topics in Quantum Electronics, 25 (1). art. no. 7201008. pp. 1-8. ISSN 1077-260X https://ieeexplore.ieee.org/document/8384018 10.1109/JSTQE.2018.2846044 |
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We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10–9 M–1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue
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Article |
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Abu Bakar, Muhammad Hafiz Mahdi, Mohd Adzir Yaacob, Mohd Hanif Amir Hamzah, Amir Syahir Lim, Hong Ngee Mustapha Kamil, Yasmin |
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Abu Bakar, Muhammad Hafiz Mahdi, Mohd Adzir Yaacob, Mohd Hanif Amir Hamzah, Amir Syahir Lim, Hong Ngee Mustapha Kamil, Yasmin Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor |
author_facet |
Abu Bakar, Muhammad Hafiz Mahdi, Mohd Adzir Yaacob, Mohd Hanif Amir Hamzah, Amir Syahir Lim, Hong Ngee Mustapha Kamil, Yasmin |
author_sort |
Abu Bakar, Muhammad Hafiz |
title |
Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor |
title_short |
Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor |
title_full |
Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor |
title_fullStr |
Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor |
title_full_unstemmed |
Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor |
title_sort |
dengue e protein detection using a graphene oxide integrated tapered optical fiber sensor |
publisher |
Institute of Electrical and Electronics Engineers |
publishDate |
2019 |
url |
http://psasir.upm.edu.my/id/eprint/81089/1/EPROTEIN.pdf http://psasir.upm.edu.my/id/eprint/81089/ https://ieeexplore.ieee.org/document/8384018 |
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