Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor

We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with dif...

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Main Authors: Abu Bakar, Muhammad Hafiz, Mahdi, Mohd Adzir, Yaacob, Mohd Hanif, Amir Hamzah, Amir Syahir, Lim, Hong Ngee, Mustapha Kamil, Yasmin
Format: Article
Language:English
Published: Institute of Electrical and Electronics Engineers 2019
Online Access:http://psasir.upm.edu.my/id/eprint/81089/1/EPROTEIN.pdf
http://psasir.upm.edu.my/id/eprint/81089/
https://ieeexplore.ieee.org/document/8384018
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Institution: Universiti Putra Malaysia
Language: English
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spelling my.upm.eprints.810892020-10-12T07:47:05Z http://psasir.upm.edu.my/id/eprint/81089/ Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor Abu Bakar, Muhammad Hafiz Mahdi, Mohd Adzir Yaacob, Mohd Hanif Amir Hamzah, Amir Syahir Lim, Hong Ngee Mustapha Kamil, Yasmin We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10–9 M–1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue diagnostics. Institute of Electrical and Electronics Engineers 2019 Article NonPeerReviewed text en http://psasir.upm.edu.my/id/eprint/81089/1/EPROTEIN.pdf Abu Bakar, Muhammad Hafiz and Mahdi, Mohd Adzir and Yaacob, Mohd Hanif and Amir Hamzah, Amir Syahir and Lim, Hong Ngee and Mustapha Kamil, Yasmin (2019) Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor. IEEE Journal of Selected Topics in Quantum Electronics, 25 (1). art. no. 7201008. pp. 1-8. ISSN 1077-260X https://ieeexplore.ieee.org/document/8384018 10.1109/JSTQE.2018.2846044
institution Universiti Putra Malaysia
building UPM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Putra Malaysia
content_source UPM Institutional Repository
url_provider http://psasir.upm.edu.my/
language English
description We report the use of a biofunctionalized tapered optical fiber based sensor with the integration of graphene oxide (GO) for the detection of Dengue virus (DENV) II E proteins. The tapered region was deposited with GO and functionalized with anti-DENV II E protein IgG antibodies to be tested with different concentrations of DENV II E proteins. The sensor obtained a detection limit of 1 pM with a sensitivity value of 12.77 nm/nM, which was better compared to previously reported studies. The sensor also showed high precision, great selectivity, and high affinity toward E protein with a dissociation constant of Kd = 1.11 × 10–9 M–1. The proposed sensor has undoubtedly exhibited the immense potential of nanomaterial integration for future advancements of dengue diagnostics.
format Article
author Abu Bakar, Muhammad Hafiz
Mahdi, Mohd Adzir
Yaacob, Mohd Hanif
Amir Hamzah, Amir Syahir
Lim, Hong Ngee
Mustapha Kamil, Yasmin
spellingShingle Abu Bakar, Muhammad Hafiz
Mahdi, Mohd Adzir
Yaacob, Mohd Hanif
Amir Hamzah, Amir Syahir
Lim, Hong Ngee
Mustapha Kamil, Yasmin
Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
author_facet Abu Bakar, Muhammad Hafiz
Mahdi, Mohd Adzir
Yaacob, Mohd Hanif
Amir Hamzah, Amir Syahir
Lim, Hong Ngee
Mustapha Kamil, Yasmin
author_sort Abu Bakar, Muhammad Hafiz
title Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
title_short Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
title_full Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
title_fullStr Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
title_full_unstemmed Dengue E protein detection using a graphene oxide integrated tapered optical fiber sensor
title_sort dengue e protein detection using a graphene oxide integrated tapered optical fiber sensor
publisher Institute of Electrical and Electronics Engineers
publishDate 2019
url http://psasir.upm.edu.my/id/eprint/81089/1/EPROTEIN.pdf
http://psasir.upm.edu.my/id/eprint/81089/
https://ieeexplore.ieee.org/document/8384018
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