Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds
Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effec...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor and Francis
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/87700/1/ABSTRACT.pdf http://psasir.upm.edu.my/id/eprint/87700/ https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1527832?journalCode=gnpl20 |
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| Institution: | Universiti Putra Malaysia |
| Language: | English |
| Summary: | Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB. |
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