Anti-inflammatory effects of mulberry (Morus alba L.) root bark and its active compounds

• Main Authors: Wu, Yong-Xiang, You, Jeong Kim, Tae, Hyung Kwon, Tan, Chin Ping, Kun, Ho Son, Kim, Taewan
• Format: Article
• Language: English
• Published: Taylor and Francis 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/87700/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/87700/; https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1527832?journalCode=gnpl20
• Institution: Universiti Putra Malaysia

Mulberry (Morus alba L.) root bark (MRB) was extracted using methanol and the extracts were subjected to tests of anti-inflammatory effects. The ethyl acetate fraction demonstrated the best anti-inflammatory effects. Purified compounds, sanggenon B, albanol B and sanggenon D, showed inhibitory effects on NO production in LPS-stimulated RAW264.7 cells and albanol B demonstrated the best anti-inflammatory effects. Regarding the underlying molecular mechanisms, further investigations showed that treatments with Albanol B reduced production of pro-inflammatory cytokines and decreased expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). These results would contribute to development of novel anti-inflammatory drugs from MRB.