Analysis of urinary metabolic alteration in type 2 diabetic rats treated with metformin using the metabolomics of quantitative spectral deconvolution 1H NMR spectroscopy

• Main Authors: M., Maulidiani, Abas, Faridah, R., Rudiyanto, Abd Kadir, Nurul Huda, Zolkeflee, Nur Khaleeda Zulaikha, Lajis, Nordin
• Format: Article
• Language: English
• Published: Elsevier 2020
• Online Access: http://psasir.upm.edu.my/id/eprint/87869/1/ABSTRACT.pdf; http://psasir.upm.edu.my/id/eprint/87869/; https://www.sciencedirect.com/science/article/pii/S0026265X19316480
• Institution: Universiti Putra Malaysia

Metformin has been used clinically as the first-choice drug to treat type 2 diabetes patients. It is not metabolized in liver and the residue which is excreted unchanged in the urine. Identification and quantification of metformin in the urine can be used as a unique marker for the metformin treated...