Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B
Prior to its total synthesis, a new vanadium coordination compound, called TSAG0101, was computationally designed to inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B). The PTP1B acts as a negative regulator of insulin signaling by blocking the active site where phosphate hydrolysis of th...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2010
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| Subjects: | |
| Online Access: | http://eprints.usm.my/38442/1/Chimeric_design%2C_synthesis%2C_and_biological_assays_of_a.pdf http://eprints.usm.my/38442/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948933/ |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |