Chimeric design, synthesis, and biological assays of a new nonpeptide insulin-mimetic vanadium compound to inhibit protein tyrosine phosphatase 1B

• Main Authors: Thomas, Scior, José Antonio, Guevara García, FJ, Melendez, H Abdallah, Hassan, Do, Quoc Tuan, Philippe, Bernard
• Format: Article
• Language: English
• Published: Dove Medical Press 2010
• Subjects: QD1-999 Chemistry
• Online Access: http://eprints.usm.my/38442/1/Chimeric_design%2C_synthesis%2C_and_biological_assays_of_a.pdf; http://eprints.usm.my/38442/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948933/
• Institution: Universiti Sains Malaysia

Prior to its total synthesis, a new vanadium coordination compound, called TSAG0101, was computationally designed to inhibit the enzyme protein tyrosine phosphatase 1B (PTP1B). The PTP1B acts as a negative regulator of insulin signaling by blocking the active site where phosphate hydrolysis of th...