Development of Polymeric Nanoparticles of Garcinia mangostana Xanthones in Eudragit RL100/RS100 for Anti-Colon Cancer Drug Delivery

• Main Authors: Abdalrahim F. A., Aisha, Abdulmajid, Amin Malik Shah, Ismail, Zhari, Alrokayan, Salman A., Abu-Salah, Khalid M.
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2015
• Subjects: RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/38679/1/Development_of_Polymeric_Nanoparticles_of_Garcinia_mangostana_Xanthones_in_Eudragit.pdf; http://eprints.usm.my/38679/; http://dx.doi.org/10.1155/2015/701979
• Institution: Universiti Sains Malaysia

Xanthones are a group of oxygenated heterocyclic compounds with anticancer properties, but poor aqueous solubility and low oral bioavailability hinder their therapeutic application. This study sought to prepare a xanthones extract (81%