Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (...
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| Main Authors: | , |
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| Format: | Book Section |
| Language: | English |
| Published: |
Penerbit Universiti Sains Malaysia
2004
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| Subjects: | |
| Online Access: | http://eprints.usm.my/42516/1/pBIO35.pdf http://eprints.usm.my/42516/ |
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| Institution: | Universiti Sains Malaysia |
| Language: | English |
| Summary: | Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been
utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (1) possessed antifungal activity against Candida albicans (MIC=68.75 μg/mL) and cytotoxic against human nasopharyngeal carcinoma cell line (KB, EC50 = 4.90 μg/mL) (Mata et al., 2001). Although the synthesis of 1 has been extensively
studied, the chemistry of this compound has only be studied in a limited extent. |
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