Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities

Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities

Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (...

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Main Authors: Ngai, Mun Hong, Sirat, Hasnah
Other Authors: Ahmad, Abdul Latif
Format: Book Section
Language:English
Published: Penerbit Universiti Sains Malaysia 2004
Subjects:
Q179.9-180 Research
Online Access:http://eprints.usm.my/42516/1/pBIO35.pdf
http://eprints.usm.my/42516/
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Institution: Universiti Sains Malaysia
Language: English
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spelling my.usm.eprints.42516 http://eprints.usm.my/42516/ Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities Ngai, Mun Hong Sirat, Hasnah Q179.9-180 Research Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (1) possessed antifungal activity against Candida albicans (MIC=68.75 μg/mL) and cytotoxic against human nasopharyngeal carcinoma cell line (KB, EC50 = 4.90 μg/mL) (Mata et al., 2001). Although the synthesis of 1 has been extensively studied, the chemistry of this compound has only be studied in a limited extent. Penerbit Universiti Sains Malaysia Ahmad, Abdul Latif Yahya, Ahmad Rahim Mohd Abdullah, Amirul AI-Ashraf Muhammad, Tengku Sifzizul Tengku 2004 Book Section PeerReviewed application/pdf en http://eprints.usm.my/42516/1/pBIO35.pdf Ngai, Mun Hong and Sirat, Hasnah (2004) Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities. In: The 4th Annual Seminar of National Science Fellowship NSF 2004 Proceedings. Penerbit Universiti Sains Malaysia, Pulau Pinang, Malaysia, pp. 181-186.
institution Universiti Sains Malaysia
building Hamzah Sendut Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sains Malaysia
content_source USM Institutional Repository
url_provider http://eprints.usm.my/
language English
topic Q179.9-180 Research
spellingShingle Q179.9-180 Research
Ngai, Mun Hong
Sirat, Hasnah
Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
description Xanthorrhizol (1) is a bisabolane-type sesquiterpenoid obtained as the main constituent of the rhizome oil of temu lawak, Curcuma xanthorrhiza, which has been utilised as a tonic in Indonesia and as a choleretic drug in Europe. As regards to its bioactivities, it has been shown that xanthorrhizol (1) possessed antifungal activity against Candida albicans (MIC=68.75 μg/mL) and cytotoxic against human nasopharyngeal carcinoma cell line (KB, EC50 = 4.90 μg/mL) (Mata et al., 2001). Although the synthesis of 1 has been extensively studied, the chemistry of this compound has only be studied in a limited extent.
author2 Ahmad, Abdul Latif
author_facet Ahmad, Abdul Latif
Ngai, Mun Hong
Sirat, Hasnah
format Book Section
author Ngai, Mun Hong
Sirat, Hasnah
author_sort Ngai, Mun Hong
title Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
title_short Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
title_full Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
title_fullStr Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
title_full_unstemmed Synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from C. xanthorrhiza and their bioactivities
title_sort synthesis of several bisabolane sesquiterpenoids from xanthorrhizol isolated from c. xanthorrhiza and their bioactivities
publisher Penerbit Universiti Sains Malaysia
publishDate 2004
url http://eprints.usm.my/42516/1/pBIO35.pdf
http://eprints.usm.my/42516/
_version_ 1643710517552873472

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