Epstein-barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: a distinct entity

• Main Authors: Zahedi, Farah Dayana, Nik Hussin, Nik Mohd. Hazleigh, Husain, Salina, Kumar, Ramesh, Gendeh, Balwant Singh
• Format: Article
• Language: English
• Published: Yuzuncu Yil Universitesi Tip Fakultesi 2017
• Subjects: QH Natural history
• Online Access: http://eprints.utm.my/id/eprint/76101/1/NikMohdHazleigh2017_Epstein-barrVirusPositivePrimarySinonasal.pdf; http://eprints.utm.my/id/eprint/76101/; https://www.journalagent.com/ejm/pdfs/EJM-76486-CASE_REPORT-ZAHEDI.pdf
• Institution: Universiti Teknologi Malaysia

Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management. We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excision was performed and examination confirmed PSNPC with positive Epstein Barr virus in-situ hybridisation. Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.