Reduction of Extracellular Proteases Increased Activity and Stability of Heterologous Protein in Aspergillus niger

The heterologous protein production in Aspergillus niger is often limited by the activity of the host extracellular proteases. To improve heterologous production, a transcription factor controlling expression of several extracellular protease-encoding genes, prtT, was deleted in A. niger PY11 and th...

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Bibliographic Details
Main Authors: Kamaruddin, Nurhaida, Storms, Reginald, Mahadi, Nor Muhammad, Md. Illias, Rosli, Abu Bakar, Farah Diba, Abdul Murad, Abdul Munir
Format: Article
Published: Springer Verlag 2018
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Online Access:http://eprints.utm.my/id/eprint/84458/
http://dx.doi.org/10.1007/s13369-017-2914-3
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Institution: Universiti Teknologi Malaysia