Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC–MS/MS

Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC–MS/MS

A selective and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the quantitative determination of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl (CCP HCl) a process related impurity in trazodone. The method provided excellent sensitivity at a typical...

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Bibliographic Details
Main Authors: Venugopal, Nandigam, Bhaskar Reddy, Ambavaram Vijaya, Madhavi, Gajulapalle, Jaafar, Jafariah, Madhavi, Vemula, Gangadhara Reddy, Kalluru
Format: Article
Language:English
Published: Elsevier B.V. 2019
Subjects:
QD Chemistry
Online Access:http://eprints.utm.my/id/eprint/89083/1/JafariahJaafar2019_TraceLevelQuantificationof1-%283-Chloropropyl%29-4-%283-Chlorophenyl%29.pdf
http://eprints.utm.my/id/eprint/89083/
http://dx.doi.org/10.1016/j.arabjc.2014.10.006
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Institution: Universiti Teknologi Malaysia
Language: English

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http://eprints.utm.my/id/eprint/89083/1/JafariahJaafar2019_TraceLevelQuantificationof1-%283-Chloropropyl%29-4-%283-Chlorophenyl%29.pdf
http://eprints.utm.my/id/eprint/89083/
http://dx.doi.org/10.1016/j.arabjc.2014.10.006

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