Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC–MS/MS
A selective and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the quantitative determination of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl (CCP HCl) a process related impurity in trazodone. The method provided excellent sensitivity at a typical...
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Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2019
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Subjects: | |
Online Access: | http://eprints.utm.my/id/eprint/89083/1/JafariahJaafar2019_TraceLevelQuantificationof1-%283-Chloropropyl%29-4-%283-Chlorophenyl%29.pdf http://eprints.utm.my/id/eprint/89083/ http://dx.doi.org/10.1016/j.arabjc.2014.10.006 |
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Institution: | Universiti Teknologi Malaysia |
Language: | English |