Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst
Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditio...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
H. : ĐHQGHN
2014
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| Online Access: | http://repository.vnu.edu.vn/handle/11126/13124 |
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| Institution: | Vietnam National University, Hanoi |
| Language: | English |
| Summary: | Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. . |
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