Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst
Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditio...
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H. : ĐHQGHN
2014
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oai:112.137.131.14:11126-131242017-10-27T01:42:21Z Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst Lưu, Văn Bôi Phạm, Hoài Thu Nguyễn, Vũ Quang Thành Doãn, Thu Hồng Nguyễn, Bích Ngọc Vũ, Thị Huệ Mạc, Đình Hùng Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. . 2014-12-11T08:57:50Z 2015-08-26T09:34:10Z 2014-12-11T08:57:50Z 2015-08-26T09:34:10Z 2013 Article 7 tr. http://repository.vnu.edu.vn/handle/11126/13124 en_US application/pdf H. : ĐHQGHN |
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Vietnam National University, Hanoi |
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VNU Library & Information Center |
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Vietnam |
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VNU Digital Repository |
| language |
English |
| description |
Pichromene 1 is a potential anti-cancer substance that is being studied for treatment of chronic leukemia. In this paper have been developed method for synthesis of pichrmene 1 and its analogs by condensation between substituted salicylaldehyde and β-nitrostyrene derivatives under different conditions (solvent, reaction time, temperature and catalyst…). The research results showed that in toluene, at a temperature of 800C, with acid L-pipecolic as catalyst, the yield of pichromenes reached 82% after 24h. The structure of the products was determined by the data of 1H-NMR and 13C-NMR spectroscopy. . |
| format |
Article |
| author |
Lưu, Văn Bôi Phạm, Hoài Thu Nguyễn, Vũ Quang Thành Doãn, Thu Hồng Nguyễn, Bích Ngọc Vũ, Thị Huệ Mạc, Đình Hùng |
| spellingShingle |
Lưu, Văn Bôi Phạm, Hoài Thu Nguyễn, Vũ Quang Thành Doãn, Thu Hồng Nguyễn, Bích Ngọc Vũ, Thị Huệ Mạc, Đình Hùng Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| author_facet |
Lưu, Văn Bôi Phạm, Hoài Thu Nguyễn, Vũ Quang Thành Doãn, Thu Hồng Nguyễn, Bích Ngọc Vũ, Thị Huệ Mạc, Đình Hùng |
| author_sort |
Lưu, Văn Bôi |
| title |
Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| title_short |
Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| title_full |
Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| title_fullStr |
Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| title_full_unstemmed |
Synthesis of Pichromenes, a Potential Anticancer Agent Using Organocatalyst |
| title_sort |
synthesis of pichromenes, a potential anticancer agent using organocatalyst |
| publisher |
H. : ĐHQGHN |
| publishDate |
2014 |
| url |
http://repository.vnu.edu.vn/handle/11126/13124 |
| _version_ |
1680966850682290176 |