Extracellular matrix in tumor biology

• Other Authors: Brekken, Rolf A. ; Stupack, Dwayne
• Format: Book
• Language: English
• Published: Springer 2020
• Subjects: Extracellular matrix ; Tumors ; Hóa sinh học; 572.6 EXT 2017
• Online Access: http://repository.vnu.edu.vn/handle/VNU_123/90780
• Institution: Vietnam National University, Hanoi

This volume provides an overview on the influence of Extracellular Matrix (ECM) on tumor progression. It covers topics such as signaling induced by structural ECM proteins including collagen and fibronectin, the control of ECM deposition and the turnover in tumors. Also discussed are the migration of cells through basement membranes and the function of proteoglycans including lumican and veriscan in tumor progression. Biomaterial-based in-vitro models as well as C. elegans models of the tumor microenvironment are used to show how these models can lead to a greater understanding of the disease mechanisms that promote cancer progression. The book addresses researchers working on cancer biology or ECM, and oncologists alike.Preface; Contents; Chapter 1: The Extracellular Matrix of Tumors: A Focus on Fibronectin and Fibulin-5; 1.1 The Function and Composition of the Extracellular Matrix; 1.2 The Role of the ECM in Tumor Development with Emphasis on FN; 1.3 Matricellular Proteins: Extracellular Modulators of the ECM; 1.4 Fibulin-5; 1.4.1 Fbln5 in Cell Adhesion/Migration; 1.4.2 Fbln5 in Proliferation/Survival; 1.4.3 Fbln5 in Angiogenesis; 1.4.4 Fbln5 in Tumor Progression; 1.5 Conclusion; References; Chapter 2: Internalization of Collagen: An Important Matrix Turnover Pathway in Cancer.