A Systematic Review on the Efficacy of Common Antacid Components

• Main Authors: Gornez, Ma. Fatima Jesuniña M., Mendoza, Hailey Vanessa G., Rapacon, Timothy P., Solano, Errol Joriz N.
• Format: text
• Published: Animo Repository 2021
• Subjects: antacid; gastroesophageal reflux disease; calcium carbonate; alginate; systematic review
• Online Access: https://animorepository.dlsu.edu.ph/conf_shsrescon/2021/paper_fnh/4; https://animorepository.dlsu.edu.ph/context/conf_shsrescon/article/1617/viewcontent/FNH_A_Systematic_Review_on_the_Efficacy_of_Common_Antacid_Components.pdf
• Institution: De La Salle University

Gastroesophageal Reflux Disease (GERD) is a common health issue worldwide that utilizes antacids to mitigate its symptoms such as chest pains and burning sensations. However, the most common component used in antacids, Aluminum Hydroxide, has a high toxicity level as it builds up in the body. Thus, this study aims to determine whether Alginate, an organic compound, and Calcium Carbonate, which is considered an age-friendly component, are suitable antacid component alternatives to Aluminum Hydroxide in terms of their corresponding Acid Neutralization Capacity (ANC) and adverse effects. The researchers utilized a systematic review approach, guided by the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P), to accomplish the study objectives. The study results suggest that Calcium Carbonate has the highest ANC while Alginate has the second-highest ANC and has fewer adverse effects than placebo. These results support the claim that Alginate and Calcium Carbonate are suitable alternatives to Aluminum Hydroxide.