Effects of cyclosporin-A on mouse kidney: A histological study
Twenty white mice (Mus musculus) were divided into four groups. The first three groups were treated with different doses of Cyclosporin-A (30, 50, 70 mg/kg/day) for 21 days. Treatment were done by mixing the given doses to their regular 5 mg food pellets. The last group served as the control group r...
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| Format: | text |
| Language: | English |
| Published: |
Animo Repository
1995
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| Online Access: | https://animorepository.dlsu.edu.ph/etd_bachelors/1266 |
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| Institution: | De La Salle University |
| Language: | English |
| Summary: | Twenty white mice (Mus musculus) were divided into four groups. The first three groups were treated with different doses of Cyclosporin-A (30, 50, 70 mg/kg/day) for 21 days. Treatment were done by mixing the given doses to their regular 5 mg food pellets. The last group served as the control group receiving the same amount of food. Cyclosporin-A effects on the kidney showed historical abnormalities. Generally, cellular edema, tubular swelling, hyalinization and lymphocyte infiltration were observed in the Cyclosporin-A treated kidneys. Increasing concentration of the drug was in parallel with the severity of the damage. Most damage was observed on the last week of treatment. |
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