Effects of cyclosporin-A on mouse kidney: A histological study

• Main Author: Bicol, John Brendon S.
• Format: text
• Language: English
• Published: Animo Repository 1995
• Subjects: Cyclosporin-A; Mice; Immunosuppressive agents; Peptides; Kidneys; Drugs
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/1266
• Institution: De La Salle University

Twenty white mice (Mus musculus) were divided into four groups. The first three groups were treated with different doses of Cyclosporin-A (30, 50, 70 mg/kg/day) for 21 days. Treatment were done by mixing the given doses to their regular 5 mg food pellets. The last group served as the control group receiving the same amount of food. Cyclosporin-A effects on the kidney showed historical abnormalities. Generally, cellular edema, tubular swelling, hyalinization and lymphocyte infiltration were observed in the Cyclosporin-A treated kidneys. Increasing concentration of the drug was in parallel with the severity of the damage. Most damage was observed on the last week of treatment.