Effects of glutaphos and L-glutamine on the histology of hepatics steatosis in mice (Mus musculus) fed with a high fat formulation
Two commercial dietary supplements, Glutaphos (a brain supplement) and LGlutamine (a muscle enhancer), were administered to mice (Mus muculus) together with forced-feeding of a lard and corn oil formulation. Thirty-six four month-old male mice were divided into 4 groups, namely Group I (negative con...
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| Main Authors: | , |
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| Format: | text |
| Language: | English |
| Published: |
Animo Repository
2009
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| Subjects: | |
| Online Access: | https://animorepository.dlsu.edu.ph/etd_bachelors/5284 |
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| Institution: | De La Salle University |
| Language: | English |
| Summary: | Two commercial dietary supplements, Glutaphos (a brain supplement) and LGlutamine (a muscle enhancer), were administered to mice (Mus muculus) together with forced-feeding of a lard and corn oil formulation. Thirty-six four month-old male mice were divided into 4 groups, namely Group I (negative control), Group II (positive control), Group III (Glutaphos) and Group IV (L-glutamine). Gross liver histology and individual hepatocytes were examined. The lard and corn oil formulation induced fatty liver in all the mice of Group II. Glutaphos-treated mice had significantly lower incidence and severity of fatty liver than the positive control. Similarly, L-glutaminetreated mice had significantly lower incidence and severity of fatty liver than the positive control. L-glutamine was significantly more effective at reducing the incidence and severity of fatty liver than Glutaphos. The proposed physiological mechanism for this effect is the ability of both Glutaphos and L-glutamine to reduce the plasma insulin:glucagon ratio which reduced lipogenesis in the liver. |
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