Effects of glutaphos and L-glutamine on the histology of hepatics steatosis in mice (Mus musculus) fed with a high fat formulation

• Main Authors: Co, Christian Oliver Co, Lujero, Leanna Karla Delos Santos
• Format: text
• Language: English
• Published: Animo Repository 2009
• Subjects: Mice—Histology; Dietary supplements—Physiological aspects; Animal Sciences; Animal Studies; Biology
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/5284
• Institution: De La Salle University

Two commercial dietary supplements, Glutaphos (a brain supplement) and LGlutamine (a muscle enhancer), were administered to mice (Mus muculus) together with forced-feeding of a lard and corn oil formulation. Thirty-six four month-old male mice were divided into 4 groups, namely Group I (negative control), Group II (positive control), Group III (Glutaphos) and Group IV (L-glutamine). Gross liver histology and individual hepatocytes were examined. The lard and corn oil formulation induced fatty liver in all the mice of Group II. Glutaphos-treated mice had significantly lower incidence and severity of fatty liver than the positive control. Similarly, L-glutaminetreated mice had significantly lower incidence and severity of fatty liver than the positive control. L-glutamine was significantly more effective at reducing the incidence and severity of fatty liver than Glutaphos. The proposed physiological mechanism for this effect is the ability of both Glutaphos and L-glutamine to reduce the plasma insulin:glucagon ratio which reduced lipogenesis in the liver.