Toxicity analysis of a mixture of triterpenes from Makopa [Syzygium samarangense (Blume) Merr. and Perry (Myrtaceae)] on zebrafish (Danio Rerio) embryos

• Main Authors: De Guzman, Vernon Joseph A., Olasiman, Wileen Zoe P.
• Format: text
• Language: English
• Published: Animo Repository 2010
• Subjects: Syzygium > Analysis; Syzygium—Toxicology; Logperch—Spermatozoa—Morphology; Biology; Plant Biology; Toxicology
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/5283
• Institution: De La Salle University

Syzygium samarangense (Blume) Merr. and Perry locally known as Makopa (Tag.), is a popular backyard tree in the Philippines. Folklorically, it has been used to treat fever and diarrhea. In this study, dechorionated zebrafish embryos and embryos with intact chorion were exposed to a mixture of triterpenes 8a-8d at two different time points (24hpf and 36hpf). An effect on mortality was observed in dechorionated treatments at both time points, which suggests that the compounds might have a toxic effect on embryonic tissues and cannot be concluded as so. However, delayed hatching and increased mortality was observed in embryos with intact chorion, suggesting that chorionic integrity was compromised by 8a-8d treatment.