A comparative study of the level of cholesterol and triglycerides in the serum and liver of obesed mice fed with orlistat and chitosan

• Main Authors: Santiago, Harlene P., Santiago, Meriam C.
• Format: text
• Language: English
• Published: Animo Repository 2002
• Subjects: Cholesterol; Food > Cholesterol content; Serum; Blood cholesterol; Triglycerides; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etd_bachelors/6476
• Institution: De La Salle University

The proficiency of a synthetic drug, Orlistat versus a natural dietary supplement, Chitosan on the lowering of cholesterol levels and Triglyceride levels of the blood serum and liver of obese Swiss mice after three weeks of feeding were compared. Four groups of mice were fed for 6 weeks with diets as follows (1) normal group (no orlistat or chitosan) (2) chitosan group (3) orlistat group (4) both chitosan-orlistat group. After 6 weeks, cholesterol levels and triglyceride levels were determined by absorption spectroscopy. The normal group had the highest level of cholesterol and triglyceride in both the blood serum and liver compared to the other three groups of mice while the chitosan-orlistat group had the lowest. Only the normal group had gained weight and all the groups that had taken the dietary pills had lost weight. The chitosan-orlistat group had the lost the highest amount of weight and the chitosan group had the lowest. Results are in agreement with previous studies. In summary, a combination of orlistat and chitosan resulted in the greatest decease in weight, liver and serum cholesterol and triglyceride, exhibiting an additive effect compared to the orlistat and chitosan groups.