Bioactive thiophene derivative and diterpene from chrysanthemum coronarium L
Two compounds: N-isobutyl-6-(2-thiophenyl)-2-4-hexadienamide and entkaurane-3,16-diol were isolated from chloroform extract of the leaves of Chrysanthemum coronarium. Their structures were elucidated by extensive ID and 2D NMR spectroscopy and mass spectrometry. The first compound was found to reduc...
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| Format: | text |
| Language: | English |
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Animo Repository
1998
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| Online Access: | https://animorepository.dlsu.edu.ph/etd_masteral/1915 https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=8753&context=etd_masteral |
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| Institution: | De La Salle University |
| Language: | English |
| Summary: | Two compounds: N-isobutyl-6-(2-thiophenyl)-2-4-hexadienamide and entkaurane-3,16-diol were isolated from chloroform extract of the leaves of Chrysanthemum coronarium. Their structures were elucidated by extensive ID and 2D NMR spectroscopy and mass spectrometry. The first compound was found to reduce the number of micronucleated polychromatic erythrocyte induced by mitomycin C by 66.5 percent at a dosage of 8 mg/kg. Thus, it is an antimutagen. Both compounds are specifically active against the fungal microorganisms, C. albicans and T. mentagrophytes.For bacterial organism, the first compound was found to be active against B. subtilis and P. aeruginosa, and inactive against S. aureus and E. coli. The second compound was found active against B. subtilis and S. aureus, and inactive against P. aeruginosa and E. coli. |
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