A new oxetane derivative from Gliricidia sepium (Jacq.) and an antimicrobial and an antimutagenic anthraquinone from Cassia alata (Linn.)

A new oxetane derivative from Gliricidia sepium (Jacq.) and an antimicrobial and an antimutagenic anthraquinone from Cassia alata (Linn.)

Two Philippine medicinal plants: Gliricidia sepium and Cassia alata are studied for their secondary metabolites. The chloroform extract of Gliricidia sepium afforded a new oxetane derivative whose structure was elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Cassia alata le...

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Bibliographic Details
Main Author: Hofilena, Joy Granada
Format: text
Language:English
Published: Animo Repository 1999
Subjects:
Medicinal plants
Chemistry
Organic
Plants
Useful
Gliricidia sepium
Trees
Antimutagens
Anti-infective agents
Extraction (Chemistry)
Medicinal-Pharmaceutical Chemistry
Organic Chemistry
Online Access:https://animorepository.dlsu.edu.ph/etd_masteral/1985
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Institution: De La Salle University
Language: English
Description
Summary:Two Philippine medicinal plants: Gliricidia sepium and Cassia alata are studied for their secondary metabolites. The chloroform extract of Gliricidia sepium afforded a new oxetane derivative whose structure was elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Cassia alata leaves afforded 1,8-dihydroxy-3-hydroxymethyl-anthraquinone. Its structure was elucidated by extensive 1D and 2D NMR, IR and UV spectroscopy and mass spectrometry. It was found active against Bacillus subtilis with an activity index of 1.8 which is higher than the standard antibiotic chloramphenicol. It reduced the number of micronucleated polychromatic etythrocytes induced by Mitomycin C by 71 percent. Thus, it is an antimutagen.

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