A new oxetane derivative from Gliricidia sepium (Jacq.) and an antimicrobial and an antimutagenic anthraquinone from Cassia alata (Linn.)

• Main Author: Hofilena, Joy Granada
• Format: text
• Language: English
• Published: Animo Repository 1999
• Subjects: Medicinal plants; Chemistry; Organic; Plants; Useful; Gliricidia sepium; Trees; Antimutagens; Anti-infective agents; Extraction (Chemistry); Medicinal-Pharmaceutical Chemistry; Organic Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etd_masteral/1985
• Institution: De La Salle University

Two Philippine medicinal plants: Gliricidia sepium and Cassia alata are studied for their secondary metabolites. The chloroform extract of Gliricidia sepium afforded a new oxetane derivative whose structure was elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. Cassia alata leaves afforded 1,8-dihydroxy-3-hydroxymethyl-anthraquinone. Its structure was elucidated by extensive 1D and 2D NMR, IR and UV spectroscopy and mass spectrometry. It was found active against Bacillus subtilis with an activity index of 1.8 which is higher than the standard antibiotic chloramphenicol. It reduced the number of micronucleated polychromatic etythrocytes induced by Mitomycin C by 71 percent. Thus, it is an antimutagen.