Antimicrobial triterpenes from Lantana camara, Linn

• Main Author: Barre, Juanita Tarro
• Format: text
• Language: English
• Published: Animo Repository 1996
• Subjects: Terpenes; Assaying; Microbial sensitivity tests; Extraction (chemistry); Verbenaceae; Lantana; Biochemistry, Biophysics, and Structural Biology; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/etd_masteral/2489; https://animorepository.dlsu.edu.ph/cgi/viewcontent.cgi?article=9327&context=etd_masteral
• Institution: De La Salle University

The air dried leaves of Lantana camara (family: Verbenaceae, Common name: cononitas) afforded 22 B-Dimethyacryloyloxylantanolic acid, a mixture of 22 B-Dimethyacryloyloxylantanolic acid and 22 B-Angeloyloxylantanolic acid an impure lantanolic and a novel triterpene by gravity column chromatography (dry packing). The structure of the novel compound was elucidated by NMR (1H,13C, DEPT and COSY) FT-IR spectroscopy and mass spectroscopy. The structures of the known triterpenes were determined by comparing their 1H NMR spectral data with those of the novel compound.The two pure compounds were tested for their antimicrobial potential using the paper disc diffusion method. These compounds exhibit high level of antimicrobial properties against Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli, Pseudomonas aeruginosa, Sacccharomyces cerevisiae, Aspergillus niger and Candida albicans.