The roles of allantoin in the stress responses of animals: A bibliometric review

• Main Authors: Alimad, Julienne E., Lacsamana, Rochelle Anne A., Hachaso, Elijah Gniya P., Moldes, Louise Tara Danielle H., Montecillo, Julianne Marie L.
• Format: text
• Language: English
• Published: Animo Repository 2024
• Subjects: Allantoin; Stress (Physiology); Animal Sciences
• Online Access: https://animorepository.dlsu.edu.ph/etdb_bio/83
• Institution: De La Salle University

Animals play a crucial role in maintaining biodiversity and ecosystem balance but face various stresses that require complex adaptations for survival. One adaptation involves the release of allantoin, a product of purine catabolism, which plays a significant role in mitigating stress. Despite the growing body of research on allantoin and its roles in animals under stress conditions, its biochemical properties remain relatively unexplored. With this, this paper aims to bridge existing gaps in knowledge in this field of research, assess research trends, and further investigate the role of allantoin in animals under stress conditions. This was done through a bibliometric analysis of relevant literature from 2013 to 2023 that were sourced from the Scopus database and analyzed using the CorText Manager. Several other tools were used in analyzing the relevant literature including term extraction, term-based and country-based network mapping, contingency matrix analysis, Sankey diagram visualization, and epic epoch analysis within the CorText Manager. It was found that the commonly used animal models in allantoin studies include Sprague Dawley and Wistar rats, with amino acids and enzymes playing crucial roles in the metabolic pathways leading to allantoin production. When it comes to identifying metabolites, on the other hand, techniques such as liquid chromatography and mass spectrometry are frequently employed. Notably, the analysis of terminology trends revealed the consistent use of terms like oxidative stress and uric acid in relevant literature. Ultimately, the relationships between commonly used terms in research have revealed consistent trends over time, offering valuable insights for future studies.