Structure-based virtual screening of Philippine natural products to discover novel inhibitors against mycobacterium leprae MurE ligase

• المؤلفون الرئيسيون: Hsiao, Vivien B., Sablan, Justine Beatriz C.
• التنسيق: text
• اللغة: English
• منشور في: Animo Repository 2026
• الموضوعات: Leprosy; Molecular dynamics; System analysis; Natural products—Philippines; Mycobacterium leprae; Biochemistry
• الوصول للمادة أونلاين: https://animorepository.dlsu.edu.ph/etdb_chem/42; https://animorepository.dlsu.edu.ph/context/etdb_chem/article/1049/viewcontent/2024_Sablan_Hsiao_Structure_based_Virtual_Screening_of_Philippine_Natural_Products_Full_text.pdf
• المؤسسة: De La Salle University

The emergence of drug-resistant strain in the causative agent of leprosy, Mycobacterium leprae, propels the need to find a cure and new antibacterial targets. Cytoplasmic Mur ligase enzymes involved in peptidoglycan biosynthesis have recently been reassessed as attractive targets for antibiotics, as...