Structure-based virtual screening of Philippine natural products to discover novel inhibitors against mycobacterium leprae MurE ligase

• Main Authors: Hsiao, Vivien B., Sablan, Justine Beatriz C.
• 格式: text
• 語言: English
• 出版: Animo Repository 2026
• 主題: Leprosy; Molecular dynamics; System analysis; Natural products—Philippines; Mycobacterium leprae; Biochemistry
• 在線閱讀: https://animorepository.dlsu.edu.ph/etdb_chem/42; https://animorepository.dlsu.edu.ph/context/etdb_chem/article/1049/viewcontent/2024_Sablan_Hsiao_Structure_based_Virtual_Screening_of_Philippine_Natural_Products_Full_text.pdf

The emergence of drug-resistant strain in the causative agent of leprosy, Mycobacterium leprae, propels the need to find a cure and new antibacterial targets. Cytoplasmic Mur ligase enzymes involved in peptidoglycan biosynthesis have recently been reassessed as attractive targets for antibiotics, as...