In silico analysis of aptamer for cortisol detection on biosensing applications

• Main Authors: Inoncillo, Maristela Amanda C., Manuel, Ella Pauline P., Redoble, Bea Eillen Joy S.
• Format: text
• Language: English
• Published: Animo Repository 2022
• Subjects: Hydrocortisone; Glucocorticoids—Receptors; Physics
• Online Access: https://animorepository.dlsu.edu.ph/etdb_physics/19; https://animorepository.dlsu.edu.ph/context/etdb_physics/article/1016/viewcontent/2022_Inocillo_Manuel_Redoble_In_Silico_Analysis_of_Aptamer_for_Cortisol_Detection_Full_text.pdf
• Institution: De La Salle University

We performed an in-silico approach in determining which aptamers would exhibit the strongest binding affinity to cortisol and compared it to the reference receptor Glucocorticoid receptor by analyzing the intermolecular forces (e.g. electrostatic forces and Van der Waals forces) of both enthalpic an...