Peroxisome proliferator-activated receptor gamma as a theragnostic target for mesenchymal-type glioblastoma patients

• Main Authors: Hua, Tuyen N. M., Oh, Jiwoong, Kim, Sohyun, Antonio, Jayson M., Vo, Vu T. A., Om, Jiyeon, Choi, Jong-Whan, Kim, Jeong-Yub, Jung, Chan-Woong, Park, Myung-Jin, Jeong, Yangsik
• Format: text
• Published: Animo Repository 2020
• Subjects: Peroxisomes; Glioblastoma multiforme—Treatment; Nervous System Diseases
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/11240
• Institution: De La Salle University

Glioblastomas (GBMs) are characterized by four subtypes, proneural (PN), neural, classical, and mesenchymal (MES) GBMs, and they all have distinct activated signaling pathways. Among the subtypes, PN and MES GBMs show mutually exclusive genetic signatures, and the MES phenotype is, in general, belie...